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Furthermore, under hypoxic conditions, NO can also be produced during the respiratory chain reaction [96,98,108]

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These cells excessively produce and cross-link extracellular matrix (ECM) components, such as type I collagen and fibronectin, resulting in a dense and highly organized fibrotic stroma ( Chemical Barriers Specific subpopulations of cancer-associated fibroblasts (CAFs) create a spatial “immune desert” or a “misdirected” chemotactic environment by secreting distinct chemokines