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The study, with its rigorous clinical design, confirmed that the intervention group exhibited significant improvements compared to the placebo group in menstrual cycle regularity (p=0.023), total testosterone levels (p=0.043), waist circumference (p=0.030), and quality of life (p=0.034), with no reported adverse effects ( Notably, the mechanisms of probiotics may involve modulation of gut microbiota composition, while prebiotics such as inulin-type fructans (ITF) can selectively promote the growth of beneficial bacteria like Bifidobacterium and Lactobacillus, enhancing SCFA production and subsequently improving gut barrier function, insulin sensitivity, and metabolic parameters ( 8 colony-forming unit (CFU)/g of Lactobacillus ( 6.3 Fecal microbiota transplantation FMT, an emerging microbial-based therapeutic strategy, involves the transfer of fecal microbial communities from healthy donors into the intestinal tract of patients to restore gut microbiota homeostasis ( Ruminococcus and Lactobacillus ( Lactobacillus and Clostridium to near-control levels, alongside a reduction in Prevotella
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In addition to the abovementioned benefits, emerging evidence indicates that bromelain also has beneficial effects on metabolic disorders [6,7,8]
