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Gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort are commonly reported, and product-specific warnings and contraindications apply

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In animal experiments, silymarin and silybinin are indicated to have protective effects on rat or mouse liver against hepatotoxicity in acute ethanol intoxication, carbon tetrachloride, cisplatin, thioacetamide, thallium, D-galactosamine and acetaminophen (10)