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Likewise, Prx5, the last identified member of the six mammalian Prxs (Van der Eecken et al., 2011), and it has been associated with the protection of mtDNA from oxidative attacks ( 2 O 2 is modest (Zhu et al., 2012)

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Consequently, simulations suggest that while doxorubicin redox metabolism impacts GSH metabolism, the concentrations required to illicit a toxic response, with either a single or extended exposure, reside outside that of the therapeutic dosing range