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After reviewing these relevant studies, 13 studies demonstrated that lycopene could significantly refine the clinical manifestations of OSF patients, among which 12 randomized controlled trial (RCT) studies have compared the potential efficacy between lycopene and other treatment modalities or the combinational effectiveness of lycopene with other drugs, apart from one study by Arakeri et al

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FIGURE 6 The future of OA care is poised to be transformed by innovations in systems biology, biomaterials, digital health, and pharmacology