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Upon release of the IL-17 family (IL-17A, IL-17C, IL-17F), IL-17A and IL-17F bind with the IL-17RA/RC receptor, and IL-17 binds with the IL-17RA/RE receptor, forming a receptor complex

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In response to growth signals, mTORC1 activates ATF4, which stimulates the expression of core enzymes in serine synthesis and the folate cycle for de novo purine synthesis required for DNA replication and ribosome biogenesis in rapidly growing and proliferating tumor cells (Denicola et al., 2019)