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The case reports presented in this article illustrate that a partial BH4 deficiency, as conveyed by the GCH1 rs841 variant, may contribute to wider issues in mental and neurological health including depression and ADHD but also severe treatment-resistant anxiety, Premenstrual Dysphoric Disorder, insomnia, complex behavioral issues, and autism

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Conclusions and Perspectives For a long time, H 2 O 2 has been considered not only a simple by-product of oxidative stress in plants but also a molecule involved in the regulation of gene expression during the exposure of plants to biotic and abiotic stresses [9,80,81]