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Our APAP model [10] is simple because it does not include the processing of GSH in the mitochondria that has been shown to be fundamental for liver cell death in the presence of APAP [36]

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Markedly, multiple organ lesions in the heart, lung, liver, kidney, and gastrointestinal tract, in particular, as well as brain lesions, were attenuated, and oxidative stress was reduced in tissues (Vukojevic et al., 2018