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Among microbial sources, fungi represent an interesting source for industrial enzymes, sharing with more than one has of enzymes in the market [3]

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There are several concerns in this field: firstly, despite the association of the mitochondria-derived peptide MOTS-c with bone metabolism and current studies confirming the effects of MOTS-c intervention, the role and mechanism of endogenous skeletal MOTS-c in regulating bone metabolism have not been evaluated