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M-CSF (also called CSF-1) is also a chemokine for macrophages and is secreted by a variety of stromal cells and epithelial cells (Wyckoff et al., 2004)

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In vitro and in vivo models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expressions of GCLC, GCLM and SLC7A11 were down-regulated, thereby disrupting the metabolism of glutathione