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During metabolic processes within cells, ROS such as superoxide anion radical (O 2 −• ), hydroxyl radical ( • OH), singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), nitric oxide (NO), and peroxynitrite (ONOO − ) are also generated
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Hst3p, a key sirtuin histone deacetylase, mediates H3K56 deacetylation to maintain chromatin repression, and its inhibition leads to genome-wide H3K56ac enrichment, which further dysregulates the transcription of virulence-associated genes including adhesins, phenotypic switching regulators and hyphal formation-related factors, thereby disrupting yeast-hyphae transition, white-opaque switching and host adhesion processes essential for C