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Data from almost 300 studies of several human cancers, including more than 70,000 patients showed conflicting effects of macrophages on patient prognosis since earlier studies failed to distinguish between M1 and M2 macrophages

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A loss-of-function mutation in the ZIP13 gene has been associated with Ehlers-Danlos syndrome, which is characterized by decreased white adipose tissue mass, among other pathological manifestations (269)

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