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Our data indicated that the 13 C satellite of GlxH2 ( 13 C-GlxH2) could be easily detected visually (Fig.3a) and quantified, although the CRLBs remained high (CRLB(GlxH2 tf )= 76%±27%) due to the low labelling concentration (Supplementary Fig.3)

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Molecular studies have identified nearly 300 genes differentially expressed in melasma-affected skin, highlighting its remarkable biological complexity and multifactorial etiology [2]