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Before jumping into the week-by-week timeline, here are key factors that affect how fast glutathione works in your body and skin: Formulation & bioavailability (standard vs liposomal vs reduced form) Dosage & consistency Diet, sleep, antioxidants, and detox capacity Skin type, pigmentation severity, sun exposure Other skin-care practices (topicals, sunscreen, treatments) Genetic and metabolic factors Given these variables, improvements tend to follow a gradual, cumulative path rather than sudden transformations