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Clinical Trials PIANO: A national pregnancy registry of women with IBD This national prospective registry study is conducted to determine whether the rates of birth defects, miscarriages, premature births and other outcomes in women with inflammatory bowel disease (IBD) taking azathioprine/6MP or biologic therapy (Remicade, Humira, Cimzia, Tysabri, Stelara, Simponi, Entyvio, or Xeljanz) are different from those among IBD-affected women not taking these medications

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These compounds (e.g., AMG073 (Cinacalcet, Sensipar), FDA approved in 2004 and etelcalcitide (Parsabiv), approved in 2017) are effective but expensive (about $10,000 per patient per year [72]) and may be accompanied by side effects [73]