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Evidence from international studies suggests that, although physicians may possess general theoretical knowledge regarding anabolic–androgenic steroids, their clinical awareness and experience remain insufficient ( These observations underscore the urgent need for improved physician education and targeted clinical training focused on recognizing, monitoring, and managing the adverse effects associated with non-medical testosterone and anabolic–androgenic substance use

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Use of the supports having a spacer arm attached or attachment of a spacer molecule to the support before immobilization of the ligand generally solves this problem