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Figure 3 Vitamin B12 favorably modulated critical inflammatory mediators The biomarker genes CCL3 and IL1B , which were upregulated in patients despite previous glucocorticoid therapy, responded very well to treatment with B12, which reduced CCL3 mRNA levels of MOD and SEV, and IL1B of SEV, matching them to the CTRL at endpoint A ( Figures 3A–D )

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Kidney function, iron status, vitamin B12, folate, vitamin D, glucose, thyroid function, medications, diet, and symptoms can all provide important context