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This quantitative understanding is now driving the development of pathway-specific inhibitors, such as PKC-β selective antagonists, SGLT2 inhibitors, and glyoxalase-1, which have shown promise in preclinical models for breaking this cycle without globally suppressing physiologically important ROS signaling -Figure 3 (Oliveira et al., 2023

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Localization of VGLUT3, the vesicular glutamate transporter type 3, in the rat brain