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In conclusion, melanin synthesis is a highly complex process developed through billions of years of evolution to protect living organisms in educated manner from damaging effects of different spectrum of the solar light in highly dynamic fashions involving several feedback mechanisms and regulatory processes affecting cell, tissue, and organismal homeostasis

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Table 1), which contains the three Cys and one His residues necessary for NEET-type 2Fe-2S coordination (Nechushtai et al., 2012