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low magnesium can induce a pro-inflammatory, pro-atherogenic endothelial environment ( 4.2 Deficiency and cardiometabolic associations Population-based data (NHANES 1999–2020) indicate persistent magnesium intake shortfalls, with specific demographics particularly affected ( 4.3 Blood pressure effects A 2024 umbrella meta-analysis (n = 2,008) of randomized controlled trials found that magnesium supplementation lowers blood pressure, although effects were modest and varied by baseline status, dose, and treatment duration ( 4.4 Endohelial function Preliminary mechanistic studies suggest magnesium may improve surrogate vascular endpoints